Tel1 dictates the replication timing of short yeast telomeres
نویسندگان
چکیده
Running title: Tel1 ATM specifies telomere replication timing
منابع مشابه
Scientific Report Tel1 dictates the replication timing of short yeast telomeres
Telomerase action is temporally linked to DNA replication. Although yeast telomeres are normally late replicating, telomere shortening leads to early firing of subtelomeric DNA replication origins. We show that double-strand breaks flanked by short telomeric arrays cause origin firing early in S phase at late-replicating loci and that this effect on origin firing time is dependent on the Tel1 c...
متن کاملTel1ATM dictates the replication timing of short yeast telomeres
Telomerase action is temporally linked to DNA replication. Although yeast telomeres are normally late replicating, telomere shortening leads to early firing of subtelomeric DNA replication origins. We show that double-strand breaks flanked by short telomeric arrays cause origin firing early in S phase at late-replicating loci and that this effect on origin firing time is dependent on the Tel1(A...
متن کاملAt Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1
The replication time of Saccharomyces cerevisiae telomeres responds to TG1-3 repeat length, with telomeres of normal length replicating late during S phase and short telomeres replicating early. Here we show that Tel1 kinase, which is recruited to short telomeres, specifies their early replication, because we find a tel1Δ mutant has short telomeres that nonetheless replicate late. Consistent wi...
متن کاملRif1/2 and Tel1 function in separate pathways during replicative senescence.
3798 Cell Cycle Volume 10 issue 21 Telomeres, the physical ends of linear eukaryotic chromosomes, are bound by proteins that protect chromosome ends from being recognized as DNA doublestranded breaks. Telomeres shorten due to incomplete DNA replication and nucleolytic degradation. This shortening is counteracted by a specialized reverse transcriptase called telomerase. In the budding yeast Sacc...
متن کاملDependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae.
In the yeast Saccharomyces cerevisiae, chromosomes terminate with approximately 400 bp of a simple repeat poly(TG(1-3)). Based on the arrangement of subtelomeric X and Y' repeats, two types of yeast telomeres exist, those with both X and Y' (Y' telomeres) and those with only X (X telomeres). Mutations that result in abnormally short or abnormally long poly(TG(1-3)) tracts have been previously i...
متن کامل